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Home Visit Study

This study provides a unique opportunity to bring the lab directly into patient homes and provide immediate analysis of samples over an extended period of time. This longitudinal approach without the invasive and/or PEM-induced measures will be vitally important in other patient cohorts and will decrease the study impact on patients from using more invasive and impactful measures (use of 1 peripheral vein catheter for all blood samples, limits the impact on patients).

  • Jonas Bergquist, MD, PhD
  • Over 3000 samples collected and metabolomics analyzed with mass spectrometry.
  • Manuscript on metabolomics data in preparation.

STUDY HYPOTHESIS AND DESCRIPTION

Combined with clinical data and survey data, this massive data set should provide a significant picture to understand post-viral diseases.

  • Energy metabolism markers during mild mental and physical exertion analyzed on-site inpatient homes with immediate analysis of samples.
  • Samples collected every 5-15 minutes over 6-7 hours, monitoring in real time baseline compared to longitudinal data.
  • Complement this with full metabolomics screening to compare and contrast the findings in metabolic/mitochondrial disturbances over time.
  • Targeting 25 PWME (ell/SIPS) + 25 Controls + 25 Contrast (elite athletes)

 

OBJECTIVES

  • Pattern biology that corresponds to patient symptoms over the course of a day in two international cohorts (Sweden, Australia)
  • Track the biological impact of meals, social tasks, mental tasks, and exercise tasks, on ME/CFS patients compared to controls
  • Cluster patients based on similar biology-symptom dynamics.


Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

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