Orthostatic intolerance (OI) is when someone isn’t able to regulate their blood pressure and heart rate well when standing. Postural orthostatic tachycardia syndrome (POTS) is a specific type of OI characterized by a rapid increase in heart rate within minutes of standing, usually with blood pressure remaining relatively stable.
OI is a component of diagnosing ME/CFS when using both the Institute of Medicine criteria and the Canadian Consensus Criteria. In addition, POTS is a commonly occurring comorbid condition in people living with ME/CFS. Therefore, research on ME/CFS typically incorporates OI and POTS in inclusion/exclusion criteria and may measure them specifically as part of the study or evaluate them during data analysis.
OMF’s Melbourne ME/CFS Collaboration published a systematic review of OI and cerebral blood flow in ME/CFS. Read the article in Springer Nature.
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