Studying CSF to further reveal
pathogenesis mechanisms in ME/CFS

STUDY HYPOTHESIS AND DESCRIPTION

• Underlying pathological mechanisms of ME/CFS are to a large extent unknown, but the presence of autoantibodies, cytokine pattern deviations and the presentation of cognitive and autonomic nervous system related symptoms indicate the role of immunology and neuroinflammation in the pathogenesis of the disease. 
• Studying cerebrospinal fluid (CSF) could specifically provide information of the pathological processes occurring in the central nervous system.

OBJECTIVES

• Collect CSF and plasma from ME/CFS patients.
• Conduct in-house quantitative proteomics and metabolomics analysis.
• Share data with collaborative groups that want to analyze the CSF more in detail.
• Collect CSF and plasma from people with other neurological diseases (including Parkinson’s, Multiple Sclerosis, Alzheimer’s, Herpes Simplex Encephalopathy,  Neuro-covid etc) and compare to ME/CFS.